The dead included 18 women and one man, a nurse at the hospital, Mohammad Ahmad, told The Associated Press. Another 15 women were wounded, some of them in critical condition, according to the local Syrian civil defense.
No group immediately claimed responsibility for the explosion.
It was the seventh car bomb explosion in Manbij in just over a month, said Munir Mustafa, the deputy director of civil defense.
Manbij in northeastern Aleppo province continues to witness violence even after the downfall of President Bashar Assad in December.
Turkish-backed factions, known as the Syrian National Army, have clashed with the U.S.-backed Kurdish-led Syrian Democratic Forces. The factions took the city from the SDF in early December during a lightning insurgency that toppled President Bashar Assad.
A resident said the car that detonated was parked on the roadside. The recurring attacks have forced residents to become more vigilant, he said.
“There are efforts from the people of Manbij to focus on protecting some neighborhoods as well as setting up surveillance cameras in the main neighborhoods of the city,” Jameel al-Sayyed, a Manbij activist and journalist said.
Mustafa warned that the attacks in Aleppo province near Syria's second city are a threat to Syria's progress to bring about post-war security and economic recovery. Most of the explosions took place at night.
“The continued attacks on Syrian civilian areas and targeting civilians while they are trying to recover from the effects of the war of the defunct Assad regime ... threaten their lives, deepens their humanitarian tragedy, undermines educational and agricultural activities and livelihoods, and worsens the humanitarian situation in Syria,” Mustafa said.
A car bombing in Manbij on Saturday killed four civilians and wounded nine, state news agency SANA reported, citing civil defense officials.
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Chehayeb reported from Beirut.