The crash occurred around 10:55 a.m. at I-75 North and U.S. 35.
Two semi trucks, a work van and a work pickup truck were involved, according to Dayton police.
The crash closed all I-75 northbound lanes and the left lane on I-75 South for around five hours.
The area reopened around 4 p.m.
The Dayton Police Department Traffic Services Unit is investigating.
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